中文名 | LY341495 |
英文名 | LY341495 |
别名 | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 (ALPHAS)-ALPHA-氨基-ALPHA-[(1S,2S)-2-羧基环丙基]-9H-吨-9-丙酸 |
英文别名 | CS-416 LY341495 LY 341495 LY-341495 9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)- (2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID (alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid (alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495 |
CAS | 201943-63-7 |
化学式 | C20H19NO5 |
分子量 | 353.37 |
密度 | 1.432 |
沸点 | 580.8±40.0 °C(Predicted) |
酸度系数 | 2.02±0.10(Predicted) |
存储条件 | Store at RT |
体内研究 | LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.83 ml | 14.149 ml | 28.298 ml |
5 mM | 0.566 ml | 2.83 ml | 5.66 ml |
10 mM | 0.283 ml | 1.415 ml | 2.83 ml |
5 mM | 0.057 ml | 0.283 ml | 0.566 ml |
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